Category: tizuwywj

Novel protocol improves pancreatic cancer outcomes

first_img Broccoli and Brussels sprouts: Cancer foes Related Dietary link found to drug-resistant breast cancer Amino acid leucine, found in animal products and beans, blocks effectiveness of medications Locally advanced pancreatic cancer (LAPC) — a tumor that, while still confined to the pancreas, involves major abdominal blood vessels — is one of the worst forms of an already deadly tumor, as it cannot be removed surgically. Now a Massachusetts General Hospital (MGH) Cancer Center clinical trial of a treatment protocol combining intensive chemotherapy and radiation with the blood-pressure drug losartan has produced unprecedented results, allowing complete removal of the tumor in 61 percent of participants and significantly improving survival rates.“Around 40 percent of pancreatic cancer patients have either locally advanced or borderline resectable disease, with historically poor rates of successful surgery,” said Janet Murphy, an instructor in medicine in the hematology/oncology division of Mass. General’s Department of Medicine, co-lead and corresponding author of the report in JAMA Oncology. “To be able to successfully remove the primary tumor in 61 percent of patients sets a new benchmark and offers much hope. To our knowledge, this is the first LAPC clinical trial that defined surgical success as its primary outcome.”The most novel element of the trial — use of the antihypertension drug losartan — builds on the findings of co-author Rakesh K. Jain, director of the Steele Laboratories for Tumor Biology at MGH and Andrew Werk Cook Professor of Radiation Oncology at Harvard Medical School, and his colleagues. Those studies found that losartan, which targets the angiotensin signaling pathway, improved the delivery of chemotherapy drugs in animal models of breast, pancreatic, and ovarian cancer. It does so by relieving pressures in the tumor microenvironment that physically block drug delivery and reduce the supply of oxygen, which is required for the tumor-killing effects of radiation therapy. Those studies also found that cancer patients who happened to be taking losartan or similar drugs for hypertension tended to live longer than others receiving the same sorts of cancer therapies.From August 2013 through July 2017 the study enrolled 49 MGH Cancer Center patients with previously untreated LAPC. All participants received chemotherapy with a combination of fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) over a four-month period, during which they also took daily doses of losartan. After CT scan evaluation to determine whether blood vessels were still involved in the tumors, patients who no longer had vascular involvement received a short course of proton-beam radiation therapy, while those whose tumors still included major blood vessels had a longer course of conventional radiation therapy. Both groups received capecitabine chemotherapy during this period.After completing the chemoradiotherapy stage, 34 of the 49 participants were able to have their tumors removed, with 30 of those procedures successfully eliminating all evidence of cancer around the tumor. A pathologic complete response — which signifies no tumor found anywhere — was achieved for three patients. Analysis of circulating biomarkers throughout the course of the study found significant drops in the expression of TGF-β, a key element in the angiotensin-signaling pathway, indicating that losartan was having its desired effect. Both the time until recurrence and the overall survival time were significantly longer than what previously had been seen in LAPC patients.“A key part of the success of our approach was our surgeons’ willingness to attempt an operation even in patients who had the appearance of cancer at or near their blood vessels,” said Murphy. “We learned in a previous study, confirmed here, that CT scan results and resectability are no longer clearly correlated after chemotherapy and radiation. While we did not see total blood vessel clearance in 61 percent of patients, 61 percent achieved a complete removal of their cancer.” Co–lead author Jennifer Wo, an assistant professor of radiation oncology, adds, “Locally advanced pancreatic cancer has been generally considered an incurable disease, so these results mark a dramatic improvement with respect both to rates of conversion to surgical resectability and to long-term disease outcomes. Based on these results we have launched a new, multi-institutional clinical trial that will also include the immunotherapy drug nivolumab, since losartan treatment has also been shown to activate several immune-system pathways.”The co-senior authors of this report are Theodore Hong, MGH Radiation Oncology, and Carlos Fernández-del Castillo, MGH Department of Surgery.Support for the study includes a National Institutes of Health Proton Beam NCI/Federal Share Program grant and the National Cancer Institute’s Cancer Clinical Investigator Team Leadership Award. Research finds compound in such cruciferous vegetables that may help to suppress tumors last_img read more

Two New COVID-19 Related Deaths Reported In Cattaraugus County

first_imgMGN ImageLITTLE VALLEY – Two additional deaths related to COVID-19 were reported in Cattaraugus County yesterday.The County Health Department says an 82-year-old man and a 95-year-old woman, both living in the southeast part of the county, developed respiratory failure and were unable to overcome their illnesses.This is the 20th and 21st related death reported since the outbreak began.Officials also announced nine new cases of COVID-19, which brings the county’s total to 558 with 99 active. Of the new cases are seven woman and two men. As of Tuesday, there are 227 residents in either mandatory or precautionary quarantine in Cattaraugus County. Share:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to email this to a friend (Opens in new window)last_img read more

Daily Dirt: Nantahala Development, DuPont Upgrades, Ranger Shot

first_imgNantahala Development in the WorksA private inholding within one of the most rugged and pristine sections of Nantahala National Forest will soon be developed, and parts of the epic Fires Creek Rim Trail system will be bulldozed to accommodate the development. The U.S. Forest Service announced that it will allow parts of the Fires Creek Trail system to be removed in order to provide road access to private landowners of the Nantahala development nearby. The easement will allow the landowners to construct, at their expense, a road across Forest Service lands to their 50-acre tract of private property. The route of access involves reconstructing and repairing portions of Rockhouse Branch Road (Forest Service Road 340A) and Phillips Ridge Road (Forest Service Road 340A1) and constructing approximately one-third of a mile of new road on Forest Service lands. The private tract is completely surrounded by U.S. Forest Service lands in the Tusquitee Ranger District of Nantahala National Forest in Western North Carolina.Park Ranger Shot, Ruled AccidentIn a sad, strange tale, a ranger was shot and a woman was killed last week on the banks of north Georgia’s Lake Lanier. Lower Buford Dam Park ranger D.P. Wright was struck in the stomach by a bullet fired by Qiana Moore. The 70-year-old Wright approached Moore as she sat in her car to tell her the park was closed when Moore shot herself. The bullet traveled through the window of her truck and into Wright, according to police. A suicide note was found in the car. Wright is expected to make a full recovery and his family says he “looks forward to returning to the job he loves and particularly interacting and teaching children about water safety.”DuPont Gets UpgradeNorth Carolina’s DuPont State Recreation Forest unveiled a significant upgrade to its infrastructure Monday. Before a crowd of hundreds, N.C. Department of Agriculture Commissioner Steve Troxler dropped the rope on two structures aimed at improving visitor safety and enjoyment. The new 120-foot-long, 10-foot-wide Hooker Falls Bridge spans the Little River from the Hooker Falls parking area on Staton Road, to the trails leading to the popular Triple and High waterfalls, while also doubling the size of the parking area. The Aleen Steinberg Welcome Center was remodeled from an existing 2,600-square-foot building, and will be the main contact point for visitors to the park.last_img read more

Voter suppression is unconstitutional and fascistic and only one political party engages in it

first_img– Advertisement – As of Nov. 4, 2020, here’s a breakdown of completed ballots, mailed in time, that have not been “processed” by Trump and the Republican party’s hampered USPS.x👀New USPS data filed in federal court this morning.Incoming ballot delivery scores 11/3:– Atlanta, 82.2%– Central PA, 61.3%– Philadelphia, 66.3%– Detroit, 78.9%– Greensboro (NC), 72.9%– Lakeland (Wisc.), 76.8%** These are completed ballots sent to election offices. **— Jacob Bogage (@jacobbogage) November 4, 2020Only one of those areas is considered “white.” It also has a population of around 1,000 people, versus say … Atlanta that has a population 500 times larger. Why is that? You know exactly why and it’s racist and it’s the definition of white supremacy and it’s by design. There are still over 300,000 mail-in ballots still unaccounted for, and the confusion and anxiety that the federal government has produced over the past few months—with Trump-appointee postmaster general Louis DeJoy’s dismantling of our postal infrastructure—is its own form of voter suppression and disenfranchisement. And while there is evidence that the USPS hasn’t specifically lost these votes as was earlier reported, the fact that the postal service under this incompetent Republican donor continues to defy a judge’s order to sweep facilities to make sure every vote is accounted for, is bullshit.- Advertisement – Republicans’ promotion of the myth of widespread “voter fraud” does reveal a kernel of truth. There is widespread constitutional fraud in our country and it has been perpetrated by the Republican Party and their wealthy, elite, and sometimes shadowy backers. The biggest fraudsters have been covered on this site and elsewhere, people like former Republican Secretary of State Kris Kobach of Kansas, who has stolen away thousands of votes, almost entirely from communities of color.In Pennsylvania, as the days pass, Republicans will push to defraud the American citizens of the Quaker state by trying to negate the counting of hundreds of thousands of votes. In Georgia, a state where the GOP stole the governor’s race away from Democratic candidate Stacey Abrams in 2018, the Republican then-Secretary of State and now-Governor Brian Kemp has “purged” somewhere approaching 1,000,000 registered voters over the last 3 years. The majority of those registered voters were and are Black. The voter suppression perpetrated by the Republican Party in Georgia has been so blatant that there is a House Oversight Committee report that highlights how much of a fraud was perpetrated on the American people under Kemp and friends. – Advertisement – xUpdate for those wondering about USPS’ methodology: Just spoke with @SamSpital, an attorney on the case. He said in all likelihood USPS simply does not know the exact percentage of mail ballots that went undelivered by Election Day deadlines (1/3)— John Kruzel (@johnkruzel) November 4, 2020Even now, after all the resources and energy the Republican Party and Donald Trump have spent on thwarting the democratic process in our country, Trump continues trying to transparently steal the election. The time and energy put in on both the federal level and the local level by these officials could have been used to say, control the spread of the COVID-19 pandemic in our country. It could have been used to begin something resembling an infrastructure plan. It could have been used for almost any of the myriad nation-building projects that even the Republican Party pretends to care about.But it wasn’t. Instead, along with packing the courts, deregulating banks and doing away with consumer protections, the Republican Party gave an enormous tax break to the wealthiest in our country, and spent the rest of the time working to solidify their very unpopular positions.Americans, even against all of these odds, came out to vote in record numbers this election, hoping to throw as much Democracy against the wall in the hopes that enough would stick in the name of justice. It remains to be seen how much we are able to salvage, but a lot did stick, and Americans and people of color are not going away. We are living in an oligarchy and it will be an uphill battle for Americans to take back their country.  Lest we forget, a group of around 200 American citizens in Graham, North Carolina, were literally pepper-sprayed by law enforcement as they marched down to vote a few days ago. The citizens were predominantly Black.Calling out voter suppression is not a new thing in progressive circles. But it is something that cannot be written about or talked about enough. We see the numbers in Texas and Florida, and there are things the Democratic Party could have done better: outreach to Latino/Latinx/Latina communities being a glaring one. But let’s not forget that Texas, with an anti-democratically packed court, was hampered by Republican Gov. Greg Abbott’s Saddam Husseinian move to limit counties to one mail-in drop-off location in each county. This move serves only one purpose: to make it that much more difficult for people to vote.- Advertisement –last_img read more

Chiron lowers estimate of flu vaccine output

first_imgOct 19, 2005 (CIDRAP News) – Chiron Corp. said this week its influenza vaccine production this year probably will be lower than the previous estimate of 18 million to 26 million doses, but officials wouldn’t predict how much lower.The company said production has been delayed by the process of correcting problems at its vaccine plant in Liverpool, England, where contamination last year forced the firm to cancel the shipment of 48 million doses to the United States.”At this point we’re out of time,” Chiron spokeswoman Alison Marquiss in Emeryville, Calif., told CIDRAP News today. “Looking ahead, we’re not 100% sure what our total number will be, but more likely than not it’ll be below the range we put out in July.”This week the company began shipping its first 1.5 million doses to US customers since the contamination problems surfaced last October.In an Oct 17 conference call with stock analysts, a transcript of which the company provided, Chiron CEO Howard Pien said the firm’s production season has been “partial and truncated.” Remediation steps at the Liverpool plant delayed the start of production, and the task of adapting to new procedures lowered output once production got under way, he explained.Pien gave no specific estimate of how many doses Chiron will produce this year. “We will supply a meaningful amount of doses to the US market, but it would most likely be fewer than the 18 million doses we spoke about in July,” he said.In response to questions, Pien said the plant’s production has not been hampered by any contamination problems. But he said some doses have been rejected in the company’s own quality-assurance process.Pien predicted that Chiron will be able to produce about 40 million doses of flu vaccine in 2006, which is expected to be a full-production season.With Chiron’s previous estimate of 18 million to 26 million doses, federal health officials had expected a US flu vaccine supply this season of about 89 million to 97 million doses. The expected contributions from other vaccine makers include 60 million doses from Sanofi Pasteur, 8 million from GlaxoSmithKline, and 3 million from MedImmune, for a total of 71 million. After the loss of Chiron’s doses last year, a total of about 60 million doses were produced for the US market.last_img read more

Mikel Arteta sends warning to Arsenal star Mesut Ozil ahead of Manchester United clash

first_img Solskjaer confident of improved Man Utd in 2020, pre-ArsenalTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 3:52FullscreenSolskjaer confident of improved Man Utd in 2020, pre-Arsenal is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.MORE: Arsenal won’t sanction Pierre-Emerick Aubameyang transfer in January Advertisement Comment Mikel Arteta sends warning to Arsenal star Mesut Ozil ahead of Manchester United clash Advertisement Ozil fell out of favour under Emery (Picture: Getty)Mikel Arteta has declared he is prepared to drop Mesut Ozil if his attitude and commitment to training drops.The Arsenal star has been plagued by inconsistency in his Emirates career and was repeatedly overlooked by Unai Emery in his final months at the club.Arteta has been tasked with rejuvenating Arsenal, but sent a blunt message to Ozil over his work-rate and place in the starting eleven.Asked if he would build his team around Ozil, Arteta replied: ‘No, I put him in the team if I see every day that his attitude, desire and understanding of what we’re trying to do is there.ADVERTISEMENT Arsenal play United in their next game (Picture: Getty)‘On his own, he can’t do it. He needs the collective structure and organisation and his team-mates.‘Nowadays, there are only one or two players in the world who can do something on their own.‘He needs help and he needs the team to play in a certain way to facilitate his strengths more and more in the game.’MORE: Arsenal scouting former Gunner Glen Kamara with view to transfer Coral BarryTuesday 31 Dec 2019 11:10 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link1.4kShares Arteta wants Ozil to continue to perform in training (Picture: Getty)‘He has the will and if he is in a better moment than somebody else, I will pick him. The moment this changes, he won’t play.’AdvertisementAdvertisementOzil has started both of Arteta’s two matches in charge so far, but received a dressing down from interim boss Freddie Ljungberg in his last game.Ljungberg hit out at Ozil’s angry reaction to being substituted in the heavy defeat to Manchester City, but Arteta urged the German to continue performing in training.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man City‘I hope he can sustain this level every three or four days. He’s putting in everything he has to try and do that, and I think his numbers physically have improved so much as well. He’s willing every day in training,’ said Arteta.‘I know him well, so I’m not surprised. I know about his ability and I know the player we have there.‘As well, the structure has to be there to be able to help him to produce everything that he has inside.last_img read more

Private finance gets its own COP26 agenda

first_imgThere would need to be action by the private sector, but “we will work with you”, and there would be actions needed by regulators and governments to catalyse the private financial sector’s efforts.Three prongs“On the road to Glasgow, we will focus on the three Rs – reporting, risk management and return – to help unlock the private financial flows that are vital to the transition,” said Carney.He called on the private finance sector to “help refine and implement” disclosure based on the Task Force on Climate-related Financial Disclosures (TCFD) framework. At the same time, the UK COP26 presidency would “work with authorities to commit to pathways to make climate reporting mandatory”.In the meantime, the private financial institutions were encouraged to contribute to a review of the current TCFD framework to allow for any improvements before disclosures became obligatory, and to demand TCFD-consistent disclosures from companies.Pension funds were specifically mentioned in the context of the net-zero goal, with Carney saying that they as well as others in the private sector “will increasingly be expected to develop and disclose their transition plans”.He said the UK COP26 presidency would be looking to build on existing work and networks, such as the Net Zero Asset Owner Alliance, Climate Action 100+, and the Principles for Responsible Investment (PRI), “to build a large coalition of asset owners and asset managers who expect their portfolio companies to become net-zero aligned”.Fiona Reynolds, CEO of the PRI, said she was “delighted that finance will play a key role at COP26 in Glasgow”.“This is the first time a host government for the COP has fully recognised the critical role that finance has to play alongside state actors and sought to prioritise its contribution,” she said.“The COP26 private finance agenda is a clear call to action for the finance industry, setting direction for a number of initiatives that have already moved from the fringes to the mainstream of our industry since COP 21”Vanessa Bingle, senior manager, Alpha FMCVanessa Bingle, senior manager at asset management consultancy Alpha FMC, said the COP26 private finance agenda was “a clear call to action for the finance industry, setting direction for a number of initiatives which have already moved from the fringes to the mainstream of our industry since COP 21”.She said the announcement “goes right to the heart of the way asset managers do business and requires firms to fully embed environmental considerations into the core of their processes, data, technology and people development. The scale of change is meaningful and asset managers must lay out concrete plans in order to keep up”.Gill Lofts, sustainable finance leader at EY, told IPE that pulling out private finance as a separate work stream was “absolutely the right thing to do” and that Carney’s speech and the associated strategy overview document “really nicely lay out some great steps to take over the next nine months to move things forward”.And there was plenty of work to be done, she said.“The detail around what firms – both public and private – need to do to build on their current sustainability metrics or how they will report and measure is not yet clear.“Banks, asset managers and insurers need to work closely with government and policy makers on this crucially important and complex matter. They will be keenly awaiting more information before they can act with real meaning and embed climate change into every financial decision they are making.” The UK has developed a climate action agenda specifically for private finance in connection with its presidency, with Italy, of this year’s United Nations (UN) climate change summit, with a preview of the strategy yesterday welcomed for providing clear direction.The agenda was unveiled at an event in London by Mark Carney, who will step down as governor of the Bank of England next month to focus on his roles as UN special envoy for climate action and finance, and COP26 finance advisor to UK prime minister Boris Johnson.In a speech, he said private finance would have a critical role to play in a successful transition to a net-zero carbon economy, and that “with the UK COP26 Presidency, in partnership with Italy, the world is watching”.The objective for the private finance work for COP26, which will unfold in Scotland in November, was to “ensure that every financial decision takes climate change into account,” he said.last_img read more

Rental demand jumps in Qld; Mackay’s vacancy rate the tightest in the state: REIQ

first_imgThe rental vacancy rate in Mackay has fallen from 1.9 per cent to 0.9 per cent in three months. Picture: Rob Maccoll.The rental vacancy rate in Mackay fell from 1.9 per cent to 0.9 per cent in just three months, which means the city is pretty much full.Rents are also on the rise, increasing in the range of 10 to 20 per cent over the past year, with two-bedroom houses and three-bedroom units reporting annual growth in the weekly median rent of $50. Mackay has the tightest rental vacancy rate in Queensland at 0.9 per cent.REIQ chief executive Antonia Mercorella said the strength of the regional economy and the employment market were driving the increase in demand for rentals.More from newsParks and wildlife the new lust-haves post coronavirus16 hours agoNoosa’s best beachfront penthouse is about to hit the market16 hours agoAbout 3900 new job opportunities were created in Mackay in the year to August — putting downward pressure on the jobless rate, which is now just 3.3 per cent.“As the state’s economy improves and the jobs market in regional Queensland strengthens, we are seeing people returning to those areas and are looking first for rental accommodation,” Ms Mercorella said. “Markets such as Mackay, Toowoomba and Bundaberg, which are tight, are stabilising after a period of correction.” Local agents take down a ‘For Rent’ sign in Cairns, which is one of the tightest coastal rental markets in Queensland.IT has become almost impossible to find a property to rent in Mackay, with the regional city’s vacancy rate now the tightest in Queensland. The latest Real Estate Institute of Queensland residential vacancy rate report shows the coastal market’s vacancy rate tightened by a whopping 100 basis points in the September quarter. REIQ chief executive Antonia Mercorella.The report found rental markets in the largest regional centres continued strengthening during the quarter as median rents trended upwards, particularly in Mackay, Rockhampton and Toowoomba.Rockhampton’s rental market moved into the tight range for the first time in six years, as vacancies shrank from 3 per cent in June to 2.3 per cent in September.The Fraser Coast and Cairns markets are the tightest coastal rental markets in Queensland with regional vacancies of 1.4 per cent.Steady rents are boosting the rental market on the Fraser Coast, with well-priced rental properties snaring a tenant in less than a week on average.The report found only two of the major regional markets in the state — Gladstone and Townsville — were weak, with vacancies above 3.5 per cent but below 4.5 per cent.Overall, the state’s rental market strengthened again in the September quarter, with 27 markets classified as tight by the REIQ, four as healthy and four as weak.The greater Brisbane rental market held steady at 2.2 per cent, but the local government area of Redland reported one of the region’s tightest vacancies of 1.5 per cent. The Brisbane LGA rental vacancy rate has tightened to 2 per cent. Image: AAP/Darren England.The Brisbane LGA tightened to 2 per cent, with vacancies for both the inner and middle ring falling to the tight range during the September quarter.“Even though this market has tightened to 2 per cent vacancies, we are hearing that pockets of the inner city are oversupplied and tenants are still negotiating well on terms,” Ms Mercorella said.She said the state’s increasing population growth would require more rental supply.last_img read more